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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

If you are taking Cialis or experiencing any side effects, please consult your doctor. They may be able to help by adjusting your dosage or spacing the medications.

C.

Cialis (tadalafil) can interact with certain foods and beverages, so it is contraindicated to use this medication with a meal that contains grapefruit or grapefruit juice.

If you are taking Cialis (tadalafil) and have any questions, please consult your doctor or pharmacist. They may have additional questions about Cialis or your medications.

D.

Cialis (tadalafil) can interact with certain foods and beverages, so it is contraindicated to use this medication with a meal that contains grapefruit or grapefruit Juice. You may be asked what other similar foods and drinks in your system may interfere with tadalafil's blood pressure-lowering effects.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Endorsed for Sexual Health and Function

C. Dose and Administration:

Cialis is taken orally, usually once daily, with or without food, as directed by a healthcare provider. It is available in 2 doses:

  1. High-dose:The recommended dose is 10 mg depending on blood pressure levels. Women who are pregnant or may become pregnant may not be taken with Cialis at the same time.
  2. Low-dose:The recommended dose is 0.5 mg taken with or without food, usually once daily. If needed, it may be taken with or without food, but it is important to follow the healthcare provider's instructions.
Chest wall health and dilation of the arteries:

D. Administration:

Cialis is taken with or without food, as directed by a healthcare provider.

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The recommended starting dose of tadalafil is 2.5 mg once daily. The doctor will prescribe a lower dose for patients with moderate or severe erectile dysfunction or those who have not responded to other ED medications. The dose may be increased to 5 mg once daily.

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Cialis information

The information on Cialis is available only with a doctor’s prescription. It is not available to everyone. It is important to have a discussion with your health care provider about any of the conditions you have. This will help ensure that Cialis is right for you.

This drug may not work as well if you take it with alcohol. Cialis is not designed to be used with grapefruit juice. Grapefruit juice can affect the metabolism of tadalafil, so it is best to limit your intake of grapefruit juice if you are taking tadalafil.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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If you experience any of the above-mentioned side effects, contact your doctor.

Signs of side effect "moderate"

e.g.,

  • You have mild indigestion
  • You have a shortness of breath
  • You have a heavy back or muscles
  • You have a stomach pain
  • You have a slow or irregular heartbeat
  • You have a halting effect
  • You have a sudden loss of vision
  • You have a blue tinge to your vision
  • You have a mood changes
  • You have nasal congestion
  • You have a sudden erection

As with all prescription medications, inform your doctor about any and all medicines you are taking as they may interact with. Cialis can interact with the following:

  • HIV protease inhibitors
  • Alpha-blockers
  • Antifungal protease inhibitors
  • Other medications

As with all prescription medications, include educated you about the side effects to seek medical attention for these signs.

In addition, let your doctor know if you are taking any of the following:

  • Doxycycline
  • Tetracycline
  • Erythromycin
  • Cimetidine
  • Phenytoin